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Article

Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell Lines

1 Jan 1999

Abstract excerpt

Spi-1/PU.1 and Fli-1 are two members of the ETS family of transcription factors whose expression is deregulated by proviral insertion in most erythroleukemic cell lines induced by the spleen focus-forming virus (SFFV) and Friend murine leukemia virus (F-MuLV) components of the Friend viral complex, respectively. In this study, we present evidence that transcription of the Fli-1 gene is positively regulated by...

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Identifiers

PMID: 9858537
DOI: 10.1128/mcb.19.1.121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell LinesPMID 9858537Read ↗

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.Semantic proximity Read ↗

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.Semantic proximity Read ↗

Spi-1/PU.1 Transgenic Mice Develop Multistep ErythroleukemiasSemantic proximity Read ↗

Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.Semantic proximity Read ↗

The Transcription Factor Spi-1/PU.1 Interacts with the Potential Splicing Factor TLSSemantic proximity Read ↗

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.Semantic proximity Read ↗

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-BSemantic proximity Read ↗

Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia.Semantic proximity Read ↗

Unexpected and coordinated expression of Spi-1, Fli-1, and megakaryocytic genes in four Epo-dependent cell lines established from transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.Semantic proximity Read ↗

Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.Semantic proximity Read ↗

Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activitySemantic proximity Read ↗

Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.Semantic proximity Read ↗

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