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Article

The Transcription Factor Spi-1/PU.1 Interacts with the Potential Splicing Factor TLS

1 Feb 1998

Abstract excerpt

Spi-1/PU.1 is an Ets protein deregulated by insertional mutagenesis during the murine Friend erythroleukemia. The overexpression of the normal protein in a proerythroblastic cell prevents its terminal differentiation. In normal hematopoiesis Spi-1/PU.1 is a transcription factor that plays a key role in normal myeloid and B lymphoid differentiation. Moreover, Spi-1/PU.1 binds RNA and interferes in vitro with the...

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Identifiers

PMID: 9478924
DOI: 10.1074/jbc.273.9.4838

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Transcription Factor Spi-1/PU.1 Interacts with the Potential Splicing Factor TLSPMID 9478924Read ↗

Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.Semantic proximity Read ↗

Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.Semantic proximity Read ↗

Spi-1/PU.1 Transgenic Mice Develop Multistep ErythroleukemiasSemantic proximity Read ↗

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AMLSemantic proximity Read ↗

Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell LinesSemantic proximity Read ↗

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.Semantic proximity Read ↗

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.Semantic proximity Read ↗

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-BSemantic proximity Read ↗

Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.Semantic proximity Read ↗

SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus.Semantic proximity Read ↗

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances ProliferationSemantic proximity Read ↗

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemiaSemantic proximity Read ↗

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