Article
Mapping of the interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2.
International journal of oncology - 1 May 2010
Olsen Birgitte B, Kreutzer Jan N, Watanabe Nobumoto, Holm Tina, Guerra Barbara
Abstract excerpt
Somatic Wee1 is a protein kinase that plays a key role in cell cycle progression at the onset of mitosis by phosphorylating CDK1 at the inhibitory Tyr15 amino acid residue. Wee1 is regulated at multiple levels, i.e., phosphorylation, protein-protein association and proteasome-mediated degradation. We have recently shown that the regulatory beta-subunit of protein kinase CK2 participates in PLK1-Wee1 complex...
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