Article

Mapping of the p53 and mdm-2 Interaction Domains

1993-07-01

Abstract excerpt

The 90-kDa cellular protein encoded by the mouse mdm-2 oncogene binds to the p53 protein in vivo and inhibits its transactivation function (J. Momand, G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine, Cell 69:1237-1245, 1992). cDNA clones encoding the human homolog of the mdm-2 protein (also called hdm-2) were isolated from a HeLa cell cDNA library. A series of monoclonal antibodies have been generated aga...

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Literature Corpus work: ff84cc00-a9da-50e9-a6cd-216cf37aefcf
DOI: 10.1128/mcb.13.7.4107-4114.1993

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