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Article

Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2).

Biochemical and biophysical research communications - 4 May 2001

Ababneh M, Götz C, Montenarh M

Abstract excerpt

We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Bin...

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Identifiers

PMID: 11327730
DOI: 10.1006/bbrc.2001.4792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11327730-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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