Article
Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.
Cellular signalling - 1 Nov 2008
Vilk Greg, Weber Jane E, Turowec Jacob P, Duncan James S, Wu Chenggang, Derksen D Richard, Zien Piotr, Sarno Stefania, Donella-Deana Arianna, Lajoie Gilles, Pinna Lorenzo A, Li Shawn S C, Litchfield David W
Abstract excerpt
Protein kinase CK2 exhibits oncogenic activity in mice and is over-expressed in a number of tumors or leukemic cells. On the basis of its amino acid sequence and a wealth of experimental information, CK2 has traditionally been classified as a protein serine/threonine kinase. In contrast to this traditional view of CK2, recent evidence has shown that CK2 can also phosphorylate tyrosine residues under some...
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