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Article

Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage

9 Mar 2012

Abstract excerpt

BACKGROUND: The DNA-dependent protein kinase (DNA-PK) is a nuclear complex composed of a large catalytic subunit (DNA-PKcs) and a heterodimeric DNA-targeting subunit Ku. DNA-PK is a major component of the non-homologous end-joining (NHEJ) repair mechanism, which is activated in the presence of DNA double-strand breaks induced by ionizing radiation, reactive oxygen species and radiomimetic drugs. We have recently...

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PMID: 22404984
DOI: 10.1186/1471-2199-13-7

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