Article
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
Cell - 2 Apr 2004
Loizou Joanna I, El-Khamisy Sherif F, Zlatanou Anastasia, Moore David J, Chan Douglas W, Qin Jun, Sarno Stefania, Meggio Flavio, Pinna Lorenzo A, Caldecott Keith W
Abstract excerpt
CK2 was the first protein kinase identified and is required for the proliferation and survival of mammalian cells. Here, we have identified an unanticipated role for CK2. We show that this essential protein kinase phosphorylates the scaffold protein XRCC1 and thereby enables the assembly and activity of DNA single-strand break repair protein complexes in vitro and at sites of chromosomal breakage. Moreover, we...
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