Article
Phosphorylation regulates the stability of the regulatory CK2beta subunit.
Oncogene - 23 May 2002
Zhang Cunjie, Vilk Greg, Canton David A, Litchfield David W
Abstract excerpt
Protein kinase CK2 is a protein serine/threonine kinase that exhibits elevated expression in a number of cancers and displays oncogenic activity in mice. The regulatory CK2beta subunit has a central role in assembly of functional tetrameric CK2 complexes where it participates in modulation of catalytic activity and substrate specificity. Since overexpression of CK2beta results in elevated levels of CK2 activity,...
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