Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of homeobox genes <i>MEIS1</i> and <i>HOXA</i> in <i>MLL</i> -rearranged acute leukemia impairs engraftment and reduces proliferation

25 Apr 2011

Abstract excerpt

Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemias. The rearrangements underlie the generation of MLL fusion proteins acting as potent oncogenes. Several most consistently up-regulated targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in other types of leukemias. Each of the four genes was knocked down...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Histone Deacetylase Inhibitors Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21518888
DOI: 10.1073/pnas.1103154108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of homeobox genes <i>MEIS1</i> and <i>HOXA</i> in <i>MLL</i> -rearranged acute leukemia impairs engraftment and reduces proliferationPMID 21518888Read ↗

<i>PBX3</i> is essential for leukemia stem cell maintenance in <i>MLL</i>‐rearranged leukemiaSemantic proximity Read ↗

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.Semantic proximity Read ↗

Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangementsSemantic proximity Read ↗

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screenSemantic proximity Read ↗

<i>Hox</i> gene Dysregulation in Acute Myeloid LeukemiaSemantic proximity Read ↗

<i>RAS</i> -mutant clones drive extramedullary acute myeloid leukemiaSemantic proximity Read ↗

MEIS1 and HOXA7 genes in human acute myeloid leukemiaSemantic proximity Read ↗

Germline <i>RUNX1</i> Variation and Predisposition to Childhood Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

HOXA9 is required for survival in human MLL-rearranged acute leukemias.Semantic proximity Read ↗

Dysregulated expression of <i>Hoxa1</i> isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromesSemantic proximity Read ↗

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.Semantic proximity Read ↗

Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AMLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.