Article
Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.
The Journal of pathology - 1 Jan 2014
Ng Ray Kit, Kong Cheuk Ting, So Chi Chiu, Lui Wing Chi, Chan Yuen Fan, Leung Ka Chun, So Kam Chung, Tsang Ho Man, Chan Li Chong, Sham Mai Har
Abstract excerpt
HOX genes are frequently dysregulated in human leukaemia with the gene rearrangement between mixed lineage leukaemia (MLL) and partner genes. The resultant MLL fusion proteins are known to mediate leukaemia through disruption of the normal epigenetic regulation at the target gene loci. To elucidate the pathogenic role of MLL fusion proteins in HOX dysregulation in leukaemia, we generated a novel haematopoietic...
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