Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

Blood - 15 Apr 2004

So Chi Wai, Karsunky Holger, Wong Piu, Weissman Irving L, Cleary Michael L

Abstract excerpt

Differential expression of Hox genes is associated with normal hematopoiesis, whereas inappropriate maintenance of Hox gene expression, particularly Hoxa7 and Hoxa9, is a feature of leukemias harboring mixed-lineage leukemia (MLL) mutations. To understand the pathogenic roles of Hox genes in MLL leukemias, we assessed the impact of Hoxa7 or Hoxa9 nullizygosity on hematopoietic progenitor compartments and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to In Vitro Techniques

Share to Leukemia, Myeloid, Acute

Share to Myeloid-Lymphoid Leukemia Protein

Share to Proto-Oncogenes

Share to Tumor Stem Cell Assay

Source

Identifiers

PMID: 15070702
DOI: 10.1182/blood-2003-10-3722

Genes

GAS7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.PMID 15070702Read ↗

Defects in Yolk Sac Hematopoiesis in Mll-Null EmbryosSemantic proximity Read ↗

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.Semantic proximity Read ↗

Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated TransformationSemantic proximity Read ↗

HOXA9 is required for survival in human MLL-rearranged acute leukemias.Semantic proximity Read ↗

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cellsSemantic proximity Read ↗

Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression.Semantic proximity Read ↗

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactionsSemantic proximity Read ↗

Altered Hox expression and segmental identity in Mll-mutant mice.Semantic proximity Read ↗

Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.Semantic proximity Read ↗

Developmental regulation of myeloerythroid progenitor function by the <i>Lin28b</i>–<i>let-7</i>–<i>Hmga2</i> axisSemantic proximity Read ↗

Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in miceSemantic proximity Read ↗

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.