Article
Aberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization.
Brain research. Molecular brain research - 1 Jul 1995
Chafetz R S, Nahm W K, Noebels J L
Abstract excerpt
Stargazer mutant mice inherit a recessive neuronal excitability phenotype featuring frequent non-convulsive spike-wave seizures that arise from synchronous bursting in neocortical, thalamic and hippocampal networks. Immunocytochemistry reveals that granule cells in the mutant dentate gyrus aberra...
Topics
- Action Potentials
- Age of Onset
- Animals
- Cell Count
- Cortical Synchronization
- Gene Expression Regulation
- Mice
- Mice, Neurologic Mutants
- Nerve Fibers
- Neurons
- Neuropeptide Y
- Phenotype
- Point Mutation
- Seizures
- Subcellular Fractions
- Transcriptional Activation