Article
Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.
The Journal of physiology - 15 Jul 2008
Singh Nanda A, Otto James F, Dahle E Jill, Pappas Chris, Leslie Jonathan D, Vilaythong Alex, Noebels Jeffrey L, White H Steve, Wilcox Karen S, Leppert Mark F
Abstract excerpt
The childhood epilepsy syndrome of benign familial neonatal convulsions (BFNC) exhibits the remarkable feature of clinical remission within a few weeks of onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of the mutant KCNQ2 or KCNQ3 potassium channels throughout adulthood. To better understand such dynamic neuroprotective plasticity within the developing brain, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.