Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.

doi:10.1016/0006-8993(91)90857-r

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Article

Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.

Brain research - 26 Jul 1991

Qiao X X, Noebels J L

Abstract excerpt

Two recessive gene loci controlling cerebral excitability in the mouse (tg, chr 8 and stg, chr 15) share generalized neocortical spike-wave seizures as a common mutant phenotype. Although the primary molecular defects are unknown, homozygous tg mutants display a gene-linked hyperplasia of central...

Topics

Animals
Brain
Electroencephalography
Epilepsy
Female
Glyoxylates
Histocytochemistry
Locus Coeruleus
Male
Methoxyhydroxyphenylglycol
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Mutation
Norepinephrine
Oxidopamine
Phenotype

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