Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.

Cell - 18 Nov 1994

Geppert M, Goda Y, Hammer R E, Li C, Rosahl T W, Stevens C F, Südhof T C

Abstract excerpt

Mice carrying a mutation in the synaptotagmin I gene were generated by homologous recombination. Mutant mice are phenotypically normal as heterozygotes, but die within 48 hr after birth as homozygotes. Studies of hippocampal neurons cultured from homozygous mutant mice reveal that synaptic transm...

Topics

Animals
Animals, Newborn
Base Sequence
Brain
Calcium
Calcium-Binding Proteins
DNA Primers
Exons
Hippocampus
Homozygote
Hypertonic Solutions
Membrane Glycoproteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Neurologic Mutants

Molecular Sequence Data

Mutagenesis

Mutation

Nerve Tissue Proteins

Source

Identifiers

PMID: 7954835
DOI: 10.1016/0092-8674(94)90556-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7954835-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.PMID 7954835Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.Semantic proximity Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.Semantic proximity Read ↗

Neural transmission. Synaptotagmin is just a calcium sensor.Semantic proximity Read ↗

Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.Semantic proximity Read ↗

Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif.Semantic proximity Read ↗

Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.Semantic proximity Read ↗

Essential functions of synapsins I and II in synaptic vesicle regulation.Semantic proximity Read ↗

PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release MachinerySemantic proximity Read ↗

Abnormal Presynaptic Short-Term Plasticity and Information Processing in a Mouse Model of Fragile X SyndromeSemantic proximity Read ↗

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.