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Article

A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman.

Biochimica et biophysica acta - 1 Dec 2015

Kirby Stephen D, Norris Joseph, Sweeney Richard, Bahnson Brian J, Cerasoli Douglas M

Abstract excerpt

Organophosphorus compounds (OPs) such as sarin and soman are some of the most toxic chemicals synthesized by man. They exert toxic effects by inactivating acetylcholinesterase (AChE) and bind secondary target protein. Organophosphorus compounds are hemi-substrates for enzymes of the serine hydrolase superfamily. Enzymes can be engineered by amino acid substitution into OP-hydrolyzing variants (bioscavengers) and...

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Identifiers

PMID: 26343853
DOI: 10.1016/j.bbapap.2015.09.001
PMCID: PMC4632840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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