Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP.

doi:10.1016/j.bbrc.2006.02.056

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Article

Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP.

Biochemical and biophysical research communications - 14 Apr 2006

Kovarik Zrinka, Ciban Nikolina, Radić Zoran, Simeon-Rudolf Vera, Taylor Palmer

Abstract excerpt

We used mouse recombinant wild-type acetylcholinesterase (AChE; EC 3.1.1.7), butyrylcholinesterase (BChE; EC 3.1.1.8), and AChE mutants with mutations (Y337A, F295L, F297I, Y72N, Y124Q, and W286A) that resemble residues found at structurally equivalent positions in BChE, to find the basis for divergence between AChE and BChE in following reactions: reversible inhibition by two oximes, progressive inhibition by...

Topics

Acetylcholinesterase
Animals
Binding Sites
Dichlorvos
Drug Interactions
Mice
Mutation
Oximes
Pralidoxime Compounds
Pyridinium Compounds
Recombinant Proteins

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Open in PubMed

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PMID: 16598855
DOI: 10.1016/j.bbrc.2006.02.056

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