Article
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.
Lancet (London, England) - 14 Oct 1995
Diepolder H M, Zachoval R, Hoffmann R M, Wierenga E A, Santantonio T, Jung M C, Eichenlaub D, Pape G R
Abstract excerpt
In acute hepatitis C virus (HCV) infection only 20-50% of patients spontaneously clear the virus. To characterise the immune reaction during that phase we studied the response of peripheral blood mononuclear cells (PBMC) to the recombinant HCV proteins core, non-structural protein 3 (NS3), NS4, and NS5 in 14 patients with acute hepatitis C. All eight patients with self-limited disease compared with two of six...
Topics
- Acute Disease
- Adult
- Aged
- Antibodies, Viral
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Leukocytes, Mononuclear
- Middle Aged
- T-Lymphocytes