Article
Effect of bottlenecking on evolution of the nonstructural protein 3 gene of hepatitis C virus during sexually transmitted acute resolving infection.
Journal of virology - 1 Dec 2005
Quer Josep, Esteban Juan Ignacio, Cos Joan, Sauleda Sílvia, Ocaña Laura, Martell María, Otero Teresa, Cubero Maria, Palou Eduard, Murillo Pedro, Esteban Rafael, Guàrdia Jaume
Abstract excerpt
Sexual partners of patients infected with the hepatitis C virus (HCV) often have detectable HCV-specific T-cell responses in the absence of seroconversion, suggesting unapparent, spontaneously resolving infection. To determine whether differences in the evolutionary potential of bottlenecked inoculum may explain the low rate of HCV persistence after sexual exposure, we have investigated changes in the entire HCV...
Topics
- Acute Disease
- Adult
- Amino Acid Sequence
- Evolution, Molecular
- Female
- Genetic Variation
- Hepacivirus
- Humans
- Male
- Molecular Sequence Data