Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of the peripheral T-Cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response.

Human immunology - 1 Jul 2003

Wang Jane H, Layden Thomas J, Eckels David D

Abstract excerpt

A disturbing feature of hepatitis C virus (HCV) is its long-term persistence in roughly 85% of those infected. Escape mutants may play a major role in HCV persistence. Our previous studies have identified a human leukocyte antigen DRB1*15 (HLA-DRB1*15) restricted Th1 epitope in the HCV NS3 protein, NS3(358-375), and escape variants of this epitope that may emerge under immune selection. Such variants attenuate or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis C Antigens

Share to Histocompatibility Antigens Class II

Share to T-Lymphocytes, Cytotoxic

Share to Th1 Cells

Share to Th2 Cells

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 12826368
DOI: 10.1016/s0198-8859(03)00070-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of the peripheral T-Cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response.PMID 12826368Read ↗

Naturally occurring CD4+ T-cell epitope variants act as altered peptide ligands leading to impaired helper T-cell responses in hepatitis C virus infection.Semantic proximity Read ↗

Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope.Semantic proximity Read ↗

Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition.Semantic proximity Read ↗

Hepatitis C virus--T-cell responses and viral escape mutations.Semantic proximity Read ↗

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection.Semantic proximity Read ↗

Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infectionSemantic proximity Read ↗

CD8 epitope escape and reversion in acute HCV infection.Semantic proximity Read ↗

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.Semantic proximity Read ↗

Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity.Semantic proximity Read ↗

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population LevelSemantic proximity Read ↗

HCV genotype-3a T cell immunity: specificity, function and impact of therapy.Semantic proximity Read ↗

Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.