Article
Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity.
World journal of gastroenterology - 28 Apr 2010
Wang Shuping, Buchli Rico, Schiller Jennifer, Gao Jianen, VanGundy Rodney S, Hildebrand William H, Eckels David D
Abstract excerpt
AIM: To understand how interactions between hepatitis C virus (HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV. METHODS: Nucleotides 3519-3935 of the non-structural 3 (NS3) region were amplified by using reverse transcription polymerase chain reaction (PCR). PCR products of the HCV NS3 regions were integrated into a PCR((R)) T7TOPO((R)) TA vector and then...
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