Article
Lack of variant specific CD8+ T-cell response against mutant and pre-existing variants leads to outgrowth of particular clones in acute hepatitis C.
Virology journal - 28 Sept 2013
Ulsenheimer Axel, Paranhos-Baccalà Gláucia, Komurian-Pradel Florence, Raziorrouh Bijan, Kurktschiev Peter, Diepolder Helmut M, Zachoval Reinhart, Spannagl Michael, Jung Maria-Christina, Gruener Norbert H
Abstract excerpt
BACKGROUND: CTL escape mutations have been described during acute hepatitis C in patients who developed chronic disease later on. Our aim was to investigate the mutual relationship between HCV specific CD8+ T cells and evolution of the viral sequence during early acute HCV infection. RESULTS: We sequenced multiple clones of NS3 1406 epitope in 4 HLA-A*02 patients with acute hepatitis C genotype 1b infection....
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