Article
Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy.
Neuroscience letters - 18 Nov 2005
Bosco Paolo, Guéant-Rodríguez Rosa-Maria, Anello Guido, Spada Rosario S, Romano Antonino, Caraci Filippo, Ferri Raffaele, Guéant Jean-Louis
Abstract excerpt
The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the epsilon 4 allele (6.3%, 95% CI: 4.2--9.4) in controls, epsilon 4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95% CI: 3.5--9.4; p<0.0001) than in most of the...
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