Article
Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy.
Neuroscience letters - 18 Nov 2005
Bosco Paolo, Guéant-Rodríguez Rosa-Maria, Anello Guido, Spada Rosario S, Romano Antonino, Caraci Filippo, Ferri Raffaele, Guéant Jean-Louis
Abstract excerpt
The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the epsilon 4 allele (6.3%, 95% CI: 4.2--9.4) in controls, epsilo...
Topics
- Age Factors
- Age of Onset
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- DNA Mutational Analysis
- Environment
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Italy
- Male
- Middle Aged
- Odds Ratio