Article
Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.
Clinical pharmacokinetics - 1 Jan 2000
Vree T B, O'Reilly W J, Hekster Y A, Damsma J E, van der Kleijn E
Abstract excerpt
The pharmacokinetics of sulphamethizole, sulphamethoxazole, sulphadiazine, sulphapyridine and sulphadimidine have been studied in man. Renal clearance values of the metabolite N4-acetylsulphonamide are 6 to 20 times higher than those of the corresponding parent compound. The renal clearance of su...
Topics
- Acetylation
- Humans
- Kidney
- Kinetics
- Phenotype
- Sulfonamides
- Time Factors