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Article

Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions.

Clinical pharmacology and therapeutics - 1 Jan 1991

Rieder M J, Shear N H, Kanee A, Tang B K, Spielberg S P

Abstract excerpt

Delayed hypersensitivity reactions are among the most severe adverse effects of the sulfonamides in current clinical use. These reactions appear to occur because of differences in the metabolism and detoxification of reactive metabolites of the sulfonamides. N-Acetylation is a major metabolic pathway for the sulfonamides. Slow acetylation phenotype might be a risk factor for the development of these reactions. We...

Topics

Acetylation
Adolescent
Caffeine
Chromatography, High Pressure Liquid
Drug Hypersensitivity
Female
Humans
Hypersensitivity, Delayed
Male
Phenotype
Sulfonamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1988235
DOI: 10.1038/clpt.1991.3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1988235-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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