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Article

Sulphamethoxazole acetylation in fast and slow acetylators.

International journal of clinical pharmacology, therapy, and toxicology - 1 Apr 1990

Bozkurt A, Basci N E, Isimer A, Tuncer M, Erdal R, Kayaalp S O

Abstract excerpt

Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of ur...

Topics

Acetylation
Adult
Aged
Female
Humans
Male
Middle Aged
Phenotype
Sulfamethazine
Sulfamethoxazole

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2338369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2338369-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Sulphamethoxazole acetylation in fast and slow acetylators.PMID 2338369Read ↗

N-acetylation phenotyping with sulphadimidine in a Turkish population.Semantic proximity Read ↗

Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.Semantic proximity Read ↗

Possible optimization of sulphadimidine dosage for acetylator phenotyping.Semantic proximity Read ↗

Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.Semantic proximity Read ↗

No effect of smoking on sulfamethazine acetylation.Semantic proximity Read ↗

N-acetylation phenotyping with sulfamethazine in an Iranian population.Semantic proximity Read ↗

Pharmacokinetics, acetylation-deacetylation, renal clearance, and protein binding of sulphamerazine, N4-acetylsulphamerazine, and N4-trideuteroacetylsulphamerazine in 'fast' and 'slow' acetylators.Semantic proximity Read ↗

N-acetylation in healthy and diseased children.Semantic proximity Read ↗

Amantadine acetylation may be effected by acetyltransferases other than NAT1 or NAT2.Semantic proximity Read ↗

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation.Semantic proximity Read ↗

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Acetylation phenotype in hypertensive patients.Semantic proximity Read ↗

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