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Article

Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.

British journal of clinical pharmacology - 1 Aug 1994

van der Ven A J, Mantel M A, Vree T B, Koopmans P P, van der Meer J W

Abstract excerpt

The formation and elimination of sulphamethoxazole hydroxylamine in relation to the pharmacokinetics of the parent compound and its N4-acetyl metabolite were investigated in six healthy subjects after a single oral dose of 800 mg sulphamethoxazole. The apparent half-lives of sulphamethoxazole and...

Topics

Acetylation
Administration, Oral
Adult
Chromatography, High Pressure Liquid
Female
Half-Life
Humans
Male
Metabolic Clearance Rate
Middle Aged
Phenotype
Sulfamethoxazole

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Identifiers

PMID: 7981016
DOI: 10.1111/j.1365-2125.1994.tb04339.x
PMCID: PMC1364861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7981016-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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