Article
Pharmacokinetics, acetylation-deacetylation, renal clearance, and protein binding of sulphamerazine, N4-acetylsulphamerazine, and N4-trideuteroacetylsulphamerazine in 'fast' and 'slow' acetylators.
Biopharmaceutics & drug disposition - 1 Jan 2000
Vree T B, Hekster C A, Baakman M, Janssen T, Oosterbaan M, Termond E, Tijhuis M
Abstract excerpt
Sulphamerazine shows a clear acetylator phenotype. The half-life of elimination of sulphamerazine is 12 h in 'fast' and 24 h in 'slow' acetylators. N4-Acetylsulphamerazine is eliminated biphasically, characterized by half-lives of 5 and 12 h in 'fast' and 5 and 24 h in 'slow' acetylators. Protein...
Topics
- Acetylation
- Creatinine
- Dealkylation
- Deuterium
- Female
- Gas Chromatography-Mass Spectrometry
- Half-Life
- Humans
- Kidney
- Kinetics
- Male
- Phenotype
- Protein Binding
- Sulfamerazine