Article
N-acetylation and oxidative capacity in aged volunteers determined with sulfamethazine and antipyrine.
International journal of clinical pharmacology, therapy, and toxicology - 1 Dec 1991
Siegmund W, Franke G, Wulkow R, Hanke W, Thonack R
Abstract excerpt
The elimination of antipyrine (AP 15 mg/kg) and sulfamethazine (SM 500 mg) was measured in healthy volunteers of rapid and slow acetylator phenotype. Nineteen males were 20-32 years of age, 11 males and 6 females between 62-86 years of age. Apparent volume of distribution of AP was reduced in adv...
Topics
- Acetylation
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Antipyrine
- Female
- Half-Life
- Humans
- Male
- Metabolic Clearance Rate
- Middle Aged
- Phenotype
- Sulfamethazine