Possible optimization of sulphadimidine dosage for acetylator phenotyping.

Abstract excerpt

The effect of different doses of sulphadimidine (250, 500, 750 and 1000 mg) on acetylation capacity in 10 normal individuals was investigated in a randomized cross-over study design. The subjects were initially phenotyped with an oral dose of 750 mg of sulphadimidine. Four weeks later, each subject was assigned four different doses of sulphadimidine. The acetylator phenotype was classified for each dose as rapid...

Topics

• Acetylation
• Administration, Oral
• Adult
• Humans
• Papua New Guinea
• Phenotype
• Random Allocation
• Sulfamethazine