Article
Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.
Clinical pharmacokinetics - 1 Jan 2000
Vree T B, Hekster Y A, Damsma J E, van der Kleijn E, O'Reilly W J
Abstract excerpt
The pharmacokinetics of N1-acetylsulphamethoxazole and N4-acetylsulphamethoxazole in man are described. N1-Acetylsulphamethoxazole is deacetylated to sulphamethoxazole and acetylated to N4-acetylsulphamethoxazole. N4-Acetylsulphamethoxazole is excreted almost unchanged in the urine. The renal exc...
Topics
- Acetylation
- Acetyltransferases
- Creatinine
- Female
- Half-Life
- Humans
- Kinetics
- Lipids
- Male
- Phenotype
- Solubility
- Sulfamethoxazole