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Article

Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.

Clinical pharmacokinetics - 1 Jan 2000

Vree T B, Hekster Y A, Damsma J E, van der Kleijn E, O'Reilly W J

Abstract excerpt

The pharmacokinetics of N1-acetylsulphamethoxazole and N4-acetylsulphamethoxazole in man are described. N1-Acetylsulphamethoxazole is deacetylated to sulphamethoxazole and acetylated to N4-acetylsulphamethoxazole. N4-Acetylsulphamethoxazole is excreted almost unchanged in the urine. The renal excretion rate is independent of the urine flow and urinary pH. N4-Acetylsulphonamides are less lipid soluble and more...

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Identifiers

PMID: 487686
DOI: 10.2165/00003088-197904040-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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