Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two induced anti-Z-DNA monoclonal antibodies use VH gene segments related to those of anti-DNA autoantibodies

1 Mar 1991

Abstract excerpt

The cDNA for H and L chain V regions of two anti-Z-DNA mAb, Z22 and Z44, were cloned and sequenced. These are the first experimentally induced anti-nucleic acid antibody sequences available for comparison with autoantibody sequences. Z22 and Z44 are IgG2b and IgG2a antibodies from C57BL/6 mice. They recognize different facets of the Z-DNA structure. They both use VH10 family genes and share 95% sequence base...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Lymphoma Diagnosis and Treatment
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1900879
DOI: 10.4049/jimmunol.146.6.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two induced anti-Z-DNA monoclonal antibodies use VH gene segments related to those of anti-DNA autoantibodiesPMID 1900879Read ↗

Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody.Semantic proximity Read ↗

Independently derived IgG anti-DNA autoantibodies from two lupus-prone mouse strains express a VH gene that is not present in most murine strains.Semantic proximity Read ↗

Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.Semantic proximity Read ↗

Structural properties and mutation patterns of anti-nucleosome monoclonal antibodies are similar to those of anti-DNA antibodies.Semantic proximity Read ↗

Variable region sequences of pathogenic anti-mouse red blood cell autoantibodies from autoimmune NZB mice.Semantic proximity Read ↗

The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strainsSemantic proximity Read ↗

Production of High Affinity Autoantibodies in Autoimmune New Zealand Black/New Zealand White F1 Mice Targeted with an Anti-DNA Heavy ChainSemantic proximity Read ↗

Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodiesSemantic proximity Read ↗

Studies on the structure, regulation, and pathogenic potential of anti-dsDNA antibodies.Semantic proximity Read ↗

Sequences of monoclonal antiphospholipid antibodies: variations on an anti-DNA antibody theme.Semantic proximity Read ↗

Molecular structure of eight human autoreactive monoclonal antibodies.Semantic proximity Read ↗

Relationships among antinuclear antibodies from autoimmune MRL mice reacting with histone H2A-H2B dimers and DNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.