Article
[Role of individual genes in the manifestation of the pathogenicity of influenza viruses].
Voprosy virusologii - 1 Jan 2000
Skovorodka V V, Farashian V R, Podcherniaeva R Ia, Zhdanov V M
Abstract excerpt
The study elucidated the role of individual genes in manifestation of mouse pathogenicity by A/PR/8/34 and A/Seal/Massachusetts/1/80. The viruses were studied by the methods of recombination and molecular hybridization. The gene analysis showed that in a permissive system the pathogenicity of A/PR/8/34 strain was not associated with HA and NA surface glycoproteins. Gene P1 plays the decisive role in manifestation...
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