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[Genetic variability of the human influenza virus during adaptation in mice].

Voprosy virusologii - 1 Jan 2000

Shilov A A, Rudneva I A, Obrosova-Serova N P, Chaĭka O V, Sinitsyn B V

Abstract excerpt

After 12 passages of a mouse-nonpathogenic influenza A/USSR/90/77 virus in mouse lungs a pathogenic virus was obtained causing death of the animals at 4-7 days after intranasal inoculation. The genetic and structural analysis of the initial and pathogenic viruses performed by oligonucleotide mapping of individual virus genes demonstrated that in the course of adaptation to mice structural changes had occurred at...

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PMID: 6495703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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