[Genetic variability of the human influenza virus during adaptation in mice].

Article

[Genetic variability of the human influenza virus during adaptation in mice].

Voprosy virusologii - 1 Jan 2000

Shilov A A, Rudneva I A, Obrosova-Serova N P, Chaĭka O V, Sinitsyn B V

Abstract excerpt

After 12 passages of a mouse-nonpathogenic influenza A/USSR/90/77 virus in mouse lungs a pathogenic virus was obtained causing death of the animals at 4-7 days after intranasal inoculation. The genetic and structural analysis of the initial and pathogenic viruses performed by oligonucleotide mapp...

Topics

Adaptation, Biological
Animals
Chromosome Mapping
Genes, Viral
Genetic Variation
Glycoproteins
Humans
Influenza A virus
Lung
Mice
Oligonucleotides
Viral Proteins
Virulence

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