Article
[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].
Genetika - 1 Apr 1993
Medvedeva T E, Kudriavtseva V K, Nevedomskaia G N, Zhikhareva I V, Gushchina M I, Zolotarev F N, Vodeĭko G M, Lisovskaia K V, Iotov V V, Khaĭder M I
Abstract excerpt
The influenza A/Leningrad/134/47/57 (H2N2) (A/Len/47) cold-adapted virus expresses the ability to reproduce at 25 degrees C (the ca phenotype) and inability to reproduce at 40 degrees C (the ts phenotype). It was attenuated for mice. Reassortants of this donor virus with the genes coding for the surface glycoproteins from the epidemic viruses, i.e. hemagglutinin (HA) and neuraminidase (NA), have been shown to be...
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