Article
[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].
Genetika - 1 Apr 1993
Medvedeva T E, Kudriavtseva V K, Nevedomskaia G N, Zhikhareva I V, Gushchina M I, Zolotarev F N, Vodeĭko G M, Lisovskaia K V, Iotov V V, Khaĭder M I
Abstract excerpt
The influenza A/Leningrad/134/47/57 (H2N2) (A/Len/47) cold-adapted virus expresses the ability to reproduce at 25 degrees C (the ca phenotype) and inability to reproduce at 40 degrees C (the ts phenotype). It was attenuated for mice. Reassortants of this donor virus with the genes coding for the...
Topics
- Acclimatization
- Animals
- Cold Climate
- Genes, Viral
- Influenza A Virus, H2N2 Subtype
- Influenza A virus
- Influenza Vaccines
- Male
- Mice
- Mice, Inbred CBA
- Orthomyxoviridae Infections
- Phenotype
- Vaccines, Attenuated