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[Changes in the biological properties of influenza virus (HON1) strains virulent for mice when exposed to homologous antibodies].

Voprosy virusologii - 1 Jan 2000

Smorodintsev A A, Ivanova N A, Medvedeva T E, Grinbaum E B, Kudriavtseva V K

Abstract excerpt

A decrease in the virulent properties of two influenza virus strains (A/PR/8/34 and A/Mel/35 (HON1) pathogenic for mice was demonstrated in multiple passages in chick embryos in the presence of homologous antibody. The artificially developed avirulent A/PR/8/240 and A/Mel/375 variants had low immunogenic activity and a marked temperature sensitivity to 40 degrees C. Common ts mutations in the genomes of these...

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PMID: 6528571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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