[Changes in the biological properties of influenza virus (HON1) strains virulent for mice when exposed to homologous antibodies].

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Article

[Changes in the biological properties of influenza virus (HON1) strains virulent for mice when exposed to homologous antibodies].

Voprosy virusologii - 1 Jan 2000

Smorodintsev A A, Ivanova N A, Medvedeva T E, Grinbaum E B, Kudriavtseva V K

Abstract excerpt

A decrease in the virulent properties of two influenza virus strains (A/PR/8/34 and A/Mel/35 (HON1) pathogenic for mice was demonstrated in multiple passages in chick embryos in the presence of homologous antibody. The artificially developed avirulent A/PR/8/240 and A/Mel/375 variants had low imm...

Topics

Animals
Antibodies, Viral
Antigens, Viral
Chick Embryo
Cricetinae
Genes, Viral
Immunization
Influenza A virus
Mice
Mutation
Rabbits
Rats
Temperature
Virulence
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 6528571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6528571-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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