Article
[Biological properties and genome structure of recombinant strains of influenza A virus differing in their degree of human virulence].
Voprosy virusologii - 1 Jan 2000
Zazimko L A, Kozinets I A, Vatlasenin A V, Vodeĭko G M, Fedotova L M
Abstract excerpt
The genome structure and some biological properties of parental and recombinant strains of influenza viruses differing by degrees of virulence for man were studied. The vaccine A/Leningrad/9/46 (H0N1) strain was shown to be markedly toxic and pathogenic for mice in contrast to influenza A/Brazil/11/78 and A/Victoria/35/72/50 viruses completely devoid of these properties. The recombinants deriving all 6 genes of...
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