[Changes in its hemagglutinin during the adaptation of the influenza virus to mice and their role in the acquisition of virulent properties and resistance to serum inhibitors].

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Article

[Changes in its hemagglutinin during the adaptation of the influenza virus to mice and their role in the acquisition of virulent properties and resistance to serum inhibitors].

Voprosy virusologii - 1 Jan 2000

Shilov A A, Sinitsyn B V

Abstract excerpt

Passages of influenza A/USSR/90/77 virus in mouse lungs produced a virulent virus (18th passage) carrying two mutations in hemagglutinin (HA) Asn127-->Asp and Tre89-->Ala. Cloning of this virus revealed two avirulent clones in the population. The analysis of one virulent (clone 7p) and one avirulent (clone 31 np) clones showed them to have both above-mentioned substitutions in HA. Clone 7p replicated in mouse...

Topics

Adaptation, Physiological
Amino Acid Sequence
Animals
Antiviral Agents
Base Sequence
Chick Embryo
Genes, Viral
Genetic Variation
Hemagglutinins, Viral
Influenza A virus
Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Serial Passage

Virulence

Virus Cultivation

Source

Open in PubMed

Identifiers

PMID: 7998391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7998391-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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