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Article

Temperature-sensitive vaccinia virus mutants identify a gene with an essential role in viral replication.

Journal of virology - 1 Feb 1990

Rempel R E, Anderson M K, Evans E, Traktman P

Abstract excerpt

Vaccinia virus mutants ts2 and ts25, members of the same complementation group, exhibit a temperature-dependent arrest at the stage of viral DNA replication. The lesions responsible for the mutant phenotypes have been localized to the far left region of the HindIII B genomic fragment by marker rescue studies. Hybrid selection analyses established that the DNA fragments positive for rescue represented the first...

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Identifiers

PMID: 2296077
DOI: 10.1128/JVI.64.2.574-583.1990
PMCID: PMC249146

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