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Article

A temperature-sensitive lesion in the small subunit of the vaccinia virus-encoded mRNA capping enzyme causes a defect in viral telomere resolution.

Journal of virology - 1 Aug 1991

Carpenter M S, DeLange A M

Abstract excerpt

Using pulsed-field gel electrophoresis, we demonstrated that the temperature-sensitive (ts) conditional lethal mutant ts9383 is, at the nonpermissive temperature, defective in the resolution of concatemeric replicative intermediate DNA to linear 185-kb monomeric DNA genomes. The resolution defect was shown to be the result of a partial failure of the mutant virus to convert the replicated form of the viral...

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Identifiers

PMID: 1649315
DOI: 10.1128/JVI.65.8.4042-4050.1991
PMCID: PMC248835

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