Article
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
Oncogene - 1 Mar 1994
Albert T, Urlbauer B, Kohlhuber F, Hammersen B, Eick D
Abstract excerpt
A panel of 18 Burkitt's lymphoma (BL) and nine other cell lines was examined for mutations in the N-terminal transactivation domain of c-Myc. Mutations leading to exchange of amino acids were detected in 13 BL but in none of the control cell lines. Mutations in c-Myc clustered between amino acid...
Topics
- Amino Acid Sequence
- Amino Acids
- Base Sequence
- Burkitt Lymphoma
- DNA Primers
- Humans
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins c-myc
- Transcriptional Activation
- Tumor Cells, Cultured