Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.

doi:10.1016/0378-1119(93)90398-m

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Article

Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.

Gene - 28 Feb 1993

Tachibana K, Takayama N, Matsuo K, Kato S, Yamamoto K, Ohyama K, Umezawa A, Takano T

Abstract excerpt

The genetic structure and regulation of the c-myc gene was comprehensively studied for the first time in Burkitt's lymphoma with t(2;8) translocation. In a Burkitt's lymphoma cell line, KOBK101, the immunoglobulin kappa-encoding gene on chromosome 2, accompanied by its enhancer, was translocated to the pvt-1 locus located about 250 kb downstream from c-myc on chromosome 8. Only the c-myc allele on the...

Topics

Alleles
Base Sequence
Blotting, Northern
Burkitt Lymphoma
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 8
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, myc
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Restriction Mapping

Transcription, Genetic

Translocation, Genetic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8444346
DOI: 10.1016/0378-1119(93)90398-m

Genes

Provenance

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