Article
The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shift.
Oncogene - 1 Nov 1991
Polack A, Strobl L, Feederle R, Schweizer M, Koch E, Eick D, Wiegand H, Bornkamm G W
Abstract excerpt
In Burkitt's lymphoma cells the c-myc gene locus is consistently fused to the constant region of one of the immunoglobulin genes by chromosomal translocation. The translocated c-myc gene is transcriptionally activated and preferentially transcribed from the P1 promoter whenever the exon-intron st...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Burkitt Lymphoma
- Cell Line
- Cells, Cultured
- Chromosome Mapping
- Cloning, Molecular
- Cricetinae
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Humans
- Immunoglobulin kappa-Chains
- Introns
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Transcription, Genetic