Article
The quantitative structure-activity relationship approach to the mutagenicity of N-nitrosomethylaniline compounds.
Mutation research - 1 Jan 2000
Jinno K
Abstract excerpt
In order to clarify the correlations between the substituent properties and the mutagenicity of N-nitrosomethylaniline compounds, the quantitative structure-activity relationship approach has been applied. The results indicate that the property and the shape of the para-substituent groups influence the mutagenic potency, although this has not yet been verified for the meta-substituted compounds.
Topics
- Aniline Compounds
- Animals
- Biotransformation
- Cricetinae
- Female
- Male
- Mesocricetus
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Nitrosamines