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Article

2-(p-Nitrophenyl)-2'-deoxyadenosine, a new type of mutagenic nucleoside.

Nucleic acids research - 11 Apr 1990

Matsuda A, Ohara Y, Kakutani T, Negishi K, Wataya Y, Hayatsu H, Ueda T

Abstract excerpt

A crude preparation of 2-phenyladenosine was found to be mutagenic in the Ames Salmonella assay. In the purification of this preparation, it was revealed that 2-phenyladenosine itself was nonmutagenic but that 2-(m- and p-nitrophenyl)-adenosines (5m,p) contaminating the sample were the mutagenic principles. A structure-activity relationship study was carried out, and it was found that 5p,...

Topics

Adenosine
Animals
Cell Line
Deoxyadenosines
Indicators and Reagents
Mammary Neoplasms, Experimental
Mice
Mutagenicity Tests
Mutagens
Mutation
Nucleosides
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 2186366
DOI: 10.1093/nar/18.7.1833
PMCID: PMC330603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2186366-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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