Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transnitrosation of non-mutagenic N-nitrosoproline forms mutagenic N-nitroso-N-methylurea.

Bioorganic & medicinal chemistry - 1 Jul 2015

Inami Keiko, Shiino Junko, Hagiwara Shin, Takeda Kei, Mochizuki Masataka

Abstract excerpt

N-Nitroso-N-methylurea (NMU) is a potent carcinogen and suspected as a cause of human cancer. In this study, mutagenic NMU was detected by HPLC after the transnitrosation of non-mutagenic N-nitrosoproline (NP) to N-methylurea in the presence of thiourea (TU) under acidic conditions. The structure of NMU was confirmed by comparing (1)H NMR and IR spectra with that of authentic NMU after fractionation by column...

Read the complete abstract on PubMed

Topics

DNA, Bacterial
Humans
Kinetics
Methylnitrosourea
Methylurea Compounds
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Nitrosamines

Nitrosation

Protons

Salmonella typhimurium

Thiourea

Source

Identifiers

PMID: 25975641
DOI: 10.1016/j.bmc.2015.04.058

Genes

NMU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transnitrosation of non-mutagenic N-nitrosoproline forms mutagenic N-nitroso-N-methylurea.PMID 25975641Read ↗

Isolation and structural identification of a direct-acting mutagen derived from N-nitroso-N-methylpentylamine and Fenton's reagent with copper ion.Semantic proximity Read ↗

Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.Semantic proximity Read ↗

UVA activation of N-dialkylnitrosamines releasing nitric oxide, producing strand breaks as well as oxidative damages in DNA, and inducing mutations in the Ames test.Semantic proximity Read ↗

Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.Semantic proximity Read ↗

Mutagenesis by N-nitroso compounds in Salmonella typhimurium TA102 and TA104: evidence for premutagenic adenine or thymine DNA adducts.Semantic proximity Read ↗

Mutagenic and Genotoxic Effect of HydroxyureaSemantic proximity Read ↗

Genotoxicity assessments of N-nitrosoethylisopropylamine (NEIPA) and N-nitrosodiisopropylamine (NDIPA) in the C57BL/6J mouse.Semantic proximity Read ↗

Apparent mutagenicity of N-nitrosothiazolidine caused by a trace contaminant.Semantic proximity Read ↗

The mutagenic action of N-ethyl-N-nitrosourea in the mouseSemantic proximity Read ↗

Development of mutagenicity during degradation of N-nitrosamines by advanced oxidation processes.Semantic proximity Read ↗

Antigenotoxic properties of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine-induced mutagenesis.Semantic proximity Read ↗

Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.