Substituent effects on the genotoxicity of 4-nitrostilbene derivatives.

doi:10.1016/0165-1218(94)90024-8

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Article

Substituent effects on the genotoxicity of 4-nitrostilbene derivatives.

Mutation research - 1 Nov 1994

Hooberman B H, Brezzell M D, Das S K, You Z, Sinsheimer J E

Abstract excerpt

4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo genotoxicity. Relative mutagenicity was studied with and without S9 activation in Salmonella strains TA98 a...

Topics

Animals
Biotransformation
Chromosome Aberrations
Male
Mice
Mutagenicity Tests
Mutation
Salmonella typhi
Stilbenes
Structure-Activity Relationship

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