Mutagenicity of isoquinoline alkaloids, especially of the aporphine type.

doi:10.1016/0165-1218(90)90077-f

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Article

Mutagenicity of isoquinoline alkaloids, especially of the aporphine type.

Mutation research - 1 Apr 1990

Nozaka T, Watanabe F, Tadaki S, Ishino M, Morimoto I, Kunitomo J, Ishii H, Natori S

Abstract excerpt

The mutagenicity of 44 isoquinoline alkaloids was tested in Salmonella typhimurium TA100 and TA98 in the presence or absence of S9 mix. The alkaloids tested included compounds from the isoquinoline, benzylisoquinoline, bisbenzylisoquinoline, monoterpene isoquinoline, berberine, morphinane, hasuba...

Topics

Alkaloids
Animals
Aporphines
Biotransformation
Dose-Response Relationship, Drug
Isoquinolines
Male
Mutagenicity Tests
Mutation
Rats
Rats, Inbred Strains
Salmonella typhimurium
Structure-Activity Relationship

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