The genotoxicity of substituted nitrobenzenes and the quantitative structure-activity relationship studies.

doi:10.1016/0045-6535(94)00450-9

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Article

The genotoxicity of substituted nitrobenzenes and the quantitative structure-activity relationship studies.

Chemosphere - 1 Mar 1995

Huang Q, Wang L, Han S

Abstract excerpt

The genotoxicity of 22 substituted nitrobenzenes was evaluated by the chromosome aberrations test in cultured human peripheral lymphocytes. 18 of 22 compounds exhibit genotoxic activities. A quantitative structure-activity relationship model was established to correlate the genotoxicity of substi...

Topics

Cell Count
Cells, Cultured
Chromosome Aberrations
Humans
Lymphocytes
Male
Mutation
Nitrobenzenes
Occupational Exposure
Regression Analysis
Structure-Activity Relationship

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