The genotoxicity of substituted nitrobenzenes and the quantitative structure-activity relationship studies.

Abstract excerpt

The genotoxicity of 22 substituted nitrobenzenes was evaluated by the chromosome aberrations test in cultured human peripheral lymphocytes. 18 of 22 compounds exhibit genotoxic activities. A quantitative structure-activity relationship model was established to correlate the genotoxicity of substituted nitrobenzenes and the characteristics of the substituents on the benzene ring.

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